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while XL is taken once a day. "If it were me and I could afford it and/or my insurance company allowed me to take it, I would err on the side of caution and take the brand name until the generics were proven at the higher doses to be bioequivalent," said Dr. Sheldon Preskorn, a professor of psychiatry at University of Kansas School of Medicine Wichita. The FDA decided to study the bioequivalence of bupropion XL 300 mg made by Impax/Teva to the brand name counterpart because of adverse events that had been reported to the agency since the generic was approved in 2006. "The adverse event reports we got included loss of antidepressant effect and, in some instances, worsening of depression symptoms, following a switch from the brand name to a generic product," Walsh said. Some patients also reported that adverse effects associated with bupropion, including headache, fatigue and anxiety, got worse after switching to Impax/Teva’s generic version, Walsh added. About half of these patients said their

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